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Update: May 22, 2019

GIDEON what’s new summary: May 19 to May 22, 2019

Infectious Diseases – Outbreaks (7 updates)

Infectious Diseases – Diseases (431 updates)

  • 358 Clinical notes
  • 32 Diseases
  • 39 Country notes
  • 2 New Disease Synonyms Added
  • Map

Microbiology – Bacteria (1 updates)

  • 1 Bacteria

Update: May 19, 2019

GIDEON what’s new summary: May 16 to May 19, 2019

Infectious Diseases – Outbreaks (9 updates)

Infectious Diseases – Diseases (166 updates)

  • 58 Diseases
  • 108 Country notes
  • Map

Infectious Diseases – Drugs (1 updates)

  • 1 Drug

Infectious Diseases – Vaccines (1 updates)

  • 1 Vaccine

Update: May 16, 2019

GIDEON what’s new summary: May 13 to May 16, 2019

Infectious Diseases – Outbreaks (8 updates)

Infectious Diseases – Diseases (80 updates)

  • 35 Diseases
  • 45 Country notes
  • Map

Infectious Diseases – Drugs (9 updates)

  • 8 Drugs
  • 1 New Drug Synonyms Added

Update: May 13, 2019

GIDEON what’s new summary: May 10 to May 13, 2019

Infectious Diseases – Outbreaks (9 updates)

Infectious Diseases – Diseases (210 updates)

  • 75 Diseases
  • 135 Country notes
  • Map

Infectious Diseases – Drugs (3 updates)

  • 3 Drugs

Update: May 10, 2019

GIDEON what’s new summary: May 7 to May 10, 2019

Infectious Diseases – Outbreaks (7 updates)

Infectious Diseases – Diseases (119 updates)

  • 5 Clinical notes
  • 39 Diseases
  • 72 Country notes
  • 3 New Disease Synonyms Added
  • Map

Update: May 7, 2019

GIDEON what’s new summary: May 4 to May 7, 2019

Infectious Diseases – Outbreaks (7 updates)

Infectious Diseases – Diseases (67 updates)

  • 3 Clinical notes
  • 26 Diseases
  • 38 Country notes
  • Map

Infectious Diseases – Drugs (2 updates)

  • 1 Drug
  • 1 Interacting drugs – New

Update: May 4, 2019

GIDEON what’s new summary: May 1 to May 4, 2019

Infectious Diseases – Diagnosis (1 updates)

  • 1 Country

Infectious Diseases – Outbreaks (10 updates)

Infectious Diseases – Diseases (195 updates)

  • 6 Clinical notes
  • 71 Diseases
  • 117 Country notes
  • 1 New Country Synonyms Added
  • Map

Microbiology – Mycobacteria (1 updates)

  • 1 Mycobacteria

Microbiology – Yeasts (1 updates)

  • 1 Yeasts

Diphtheria in Thailand

Although two fatal cases of diphtheria were recently reported in Thailand [1], rates of this disease have declined dramatically since the 1970’s.  In fact, Thailand can serve as an icon for the effectiveness of vaccination.  In the following graph, I’ve contrasted rates of diphtheria, pertussis and tetanus with WHO estimates of DPT vaccine uptake.  The second graph depicts the effect of DPT vaccination on diphtheria mortality in this country. [2,3]

References:

  1. http://www.promedmail.org/post/6453182
  2. Berger S. Infectious Diseases of Thailand, 2019. 506 pages , 169 graphs , 2,339 references. Gideon e-books,  https://www.gideononline.com/ebooks/country/infectious-diseases-of-thailand/
  3. Gideon e-Gideon multi-graph tool,   https://www.gideononline.com/cases/multi-graphs/

Note featured on ProMED

Measles: Correlation of Vaccine Uptake with Disease Rates

The following is a country-by-country analysis of measles reporting trends vs. vaccine uptake.  For purposes of consistency, incidence data and population statistics used to calculate rates per 100,000 will be limited to those published by the World Health Organization (WHO).  Resultant graphs were generated by Gideon and abstracted from the Gideon e-book series [1,2]  True estimates of vaccination update statistics are those published by WHO, in most cases available only since 1980.  Data published by the countries themselves were not used, to avoid possible bias or inconsistency when comparing data among countries. Historical disease data which precede 1980 have also been appended to graphs to further appreciate the impact of vaccination.

The reader will note that in virtually all cases, the presumed impact of vaccine uptake on disease incidence occurs when vaccine uptake exceeds 80%, and again when rates increase beyond 90%.   As such, the few countries which have not achieved 80% uptake, or have consistently reported >90% uptake since 1980 are excluded.  Graphs are not included for countries for which data are not reported, or reported only sporadically.

Individual graphs for 135 countries are presented below in alphabetical order.  In 127 (94%) of these, a clear relationship seems to exist between increasing vaccine uptake and decreasing rates of measles.  In eight cases, temporary “spikes” in disease incidence were reported during years of high vaccine uptake: Japan, Jordan, Republic of Korea, Seychelles, Solomon Islands, South Africa, Sri Lanka and Syria.

I have not attempted to perform a statistical analysis of this phenomenon, and cannot say with certainty that a confounding (third) factor does not exist.  Nevertheless, these graphs appear to indicate a favorable effect of vaccination on measles incidence.

Measles Vaccine Uptake vs. Disease rates (per 100,000)

References:

  1. Gideon e-Gideon multi-graph tool,   https://www.gideononline.com/cases/multi-graphs/
  2. Berger S. Measles: Global Status, 2019. 548 pages , 538 graphs , 5,779 references. Gideon e-books,  https://www.gideononline.com/ebooks/disease/measles-global-status/

Update: May 1, 2019

GIDEON what’s new summary: April 29 to May 1, 2019

Infectious Diseases – Outbreaks (5 updates)

Infectious Diseases – Diseases (87 updates)

  • 41 Diseases
  • 46 Country notes
  • Map

Infectious Diseases – Drugs (2 updates)

  • 2 Antibiotic testing standards – Update

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