With reference to a recent outbreak of KFD in Karanatka, India, an effective and safe vaccine has been available for over 15 years. 88,152 persons were immunized in trials during 1990 to 1992, with no report of adverse effects. The formalin-inactivated vaccine is prepared from tissue culture, and administered at a dose of 1.0 ml sc (0.5 ml below age 6), with a booster dose after 4 weeks.
The geographic distribution of this group of viruses is not restricted to Karanatka. For example, 22.4% of persons living in the Andaman and Nicobar Islands were found to be seropositive toward KFD in 2002; and closely related agents are reported in Saudi Arabia (Alkhurma virus) and China (Nanjianyin virus).
Update: Reported in ProMED