Therapy - Drugs

displays the names of the drugs that cause untoward effects and interact with antimicrobial agents in-vivo. It also displays a list of organisms from which the physician may select to find the name of the effective drugs.

The window comprises the following buttons:

Susceptibility - Choose from comprehensive list of organisms and display list of drugs know to be effective against those pathogens.
Toxicity - List of untoward effects, which may complicate antimicrobial therapy.
Interactions - List of drugs, which may interact with antimicrobial agents in-vivo.
Trade Names

Susceptibility

For purposes of this list, "active" indicates that over 50% of isolates are susceptible in-vitro or respond clinically to each of the drugs listed when appropriate dosages are employed. This designation does not imply a clinical indication for any specific drug-pathogen pair.

The drug of choice (as designated in the Medical Letter, the Sanford Guide to Antimicrobial Therapy, and other standard references) is denoted by the presence of a before the drug name. indicates that the drug is used in combination therapy. When more than one organism is selected for a Susceptibility Filter, these indicators will not appear.

Toxicity

The user should note that not all forms of toxicity are equally common among the drugs listed. GIDEON has attempted to present a comprehensive listing of potential and reported effects. Minor and local effects such as pain on injection and phlebitis are not included. In many cases, data regarding teratogenicity and contraindication in pregnancy are based on animal studies only. The use of any drug or vaccine during pregnancy must consider all alternatives, potential risks and benefits to the specific patient The incidence of specific adverse reactions has not been listed, since published figures vary considerably and are often determined by patient age, dosage, duration of therapy and other factors.

Interactions

This list does not include all instances of synergy or antagonism against the infecting pathogen, or interference with laboratory tests and reagents.

Not all of the interactions listed are common. GIDEON has opted to present a comprehensive listing of potential and reported interactions.

The letter S enclosed in carats <S> designates pathogens and infections for which surgery (excision, extraction) is often necessary. Often, multiple pathogens are identified or implicated during a given infection episode.