Microbiology - Overview
GIDEON is designed to identify the bacterial pathogens and commensals associated with man. The database includes known or estimated incidence/prevalence rates for over 900 taxa, as well at the phenotypic characteristics used in their laboratory testing. Data are entered into a Bayesian matrix, which then lists all likely taxa in descending order of probability. Laboratory profiles of individual species can then be compared and analyzed.
Data are derived from all standard texts and journals through individual and electronic search. These data are upgraded on a continual basis, and phenotypic characteristics, new taxa, and classification are automatically refined in successive Update packages.
Limitations of the Module.
The major problem in any identification program is the reliability of user input.
In some instances, phenotypic characteristics may represent a mixed culture, laboratory error or the presence of a contaminant.
The Microbiology database includes only organisms that may be grown on artificial media. Therefore Chlamydia, Rickettsia, certain treponemes, etc may not be studied through this module; however, the latter are extensively analyzed in the Epidemiology and Therapy modules. Virtually all human pathogens and commensals are listed. Phenotypic and biochemical tests were selected to reflect those generally available in routine clinical laboratories.
As such, the fine points of Mycobacterium and Legionella speciation are beyond this module.
In some cases, the laboratory test profile entered by the user is not compatible with the organisms included in GIDEON.
This may reflect:
- Inaccurate laboratory data
- A mixed culture; or
- A contaminant (e.g., fungus)
Altering Output
While running the program, the user may alter his/her listing of laboratory data. The flexible nature of data entry allows the user to consider, for example, “What if the organism in question were found to express pigment or ferment salicin?”
Updates
Microbiological data change continuously. New taxa, tests and nomenclature are constantly updated in GIDEON.
